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| 产地 | |
| 品牌 | 国产 |
| 货号 | K005358P |
| 用途 | 科研实验 |
| 英文名称 | Anti-NOTCH1 Polyclonal Antibody |
| 包装规格 | |
| 纯度 | % |
| CAS编号 | |
| 保质期 | 一年 |
| 是否进口 | 否 |
| 免疫原 | A synthetic peptide of human NOTCH1 |
|---|---|
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide of human NOTCH1 |
| Subcellular Locations | Cell membrane Nucleus Single-pass type I membrane protein |
| Swiss Prot | P46531 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. |
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