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| 产地 | |
| 品牌 | 国产 |
| 货号 | K008079P |
| 用途 | 科研实验 |
| 英文名称 | Anti-FAS Polyclonal Antibody |
| 包装规格 | |
| 纯度 | % |
| CAS编号 | |
| 保质期 | 一年 |
| 是否进口 | 否 |
| 英文名称 | Anti-FAS Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | APT1;CD95;FAS1;APO-1;FASTM;ALPS1A;TNFRSF6 |
| 应用 | WB IHC |
| 稀释比例 | WB 1:500-2000. IHC 1:25-100. |
| 交叉反应 | Human |
| 蛋白分子量 | 38kDa |
| Gene ID | 355 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | Recombinant protein of human FAS |
| 性状 | 液体 |
| Public Immunogen Range | Recombinant protein of human FAS |
| Swiss Prot | P25445 |
| Subcellular Locations | Cell membrane Secreted Single-pass type I membrane protein |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. |
注意：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
