Overview:

Euchromatichistone-lysineN-methyltransferase1(EHMT1)isinchargeofthemono-anddemethylationoflysine-9ofhistoneH3.EHMT1isfoundinamultimericproteincomplexcontainingchromatinmodifiers,whichcontributestosilencingofMYC-andE2F-responsivegenesduringG0phaseofcellcycle(1).EHMT1playsaroleinepithelial-to-mesenchymaltransitionandtumorinvasionbyrepressingexpressionoftumoursuppressorgenes(2).Additionally,EHMT1alsomethylatesnon-histoneproteinssuchaslysine-373ofp53(3).

GeneAliases:

GLP;GLP1;Eu-HMTase1;EUHMTASE1;FP13812;KMT1D;bA188C12.1

GenbankNumber:

NM_024757

References:

1.Ogawa,H.,etal.AcomplexwithchromatinmodifiersthatoccupiesE2F-andMyc-responsivegenesinG0cells.Science.296(5570):1132-6,2002.2.Kokura,K.,etal.Methyl-H3K9-bindingproteinMPP8mediatesE-cadheringenesilencingandpromotestumourcellmotilityandinvasion.EMBOJ.29(21):3673-87,2010.3.Huang,J.,etal.G9aandGlpmethylatelysine373inthetumorsuppressorp53.JBiolChem.285(13):9636-41,2010.