| 英文名称 | Anti-TPSB2 Polyclonal Antibody |
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| 宿主 | Rabbit |
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| 别名 | TPS2;tryptaseB;tryptaseC |
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| 应用 | WB IHC |
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| 稀释比例 | WB 1:500-2000. IHC 1:10-100. |
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| 交叉反应 | Human |
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| 蛋白分子量 | 31kDa |
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| Gene ID | 7177 |
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| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
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| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
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| 纯化方法 | Affinity purification |
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| 亚型 | IgG |
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| 免疫原 | Full length fusion protein |
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| 性状 | 液体 |
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| Public Immunogen Range | Full length fusion protein |
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| Subcellular Locations | Secreted |
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| Swiss Prot | P20231 |
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| 克隆类型 | Polyclonal Antibody |
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| 背景资料 | Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. |
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