Peprotech原装Recombinant Human BMP-2 120-02价格

 

 

 

Recombinant Human BMP-2

Catalog Number:

120-02

Synonyms:

BMP-2A

Description:

BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.

AA Sequence:

MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED ₅₀ for this effect is 0.5-1.0 μg/ml.

 

Peprotech原装Recombinant Human BMP-2 120-02价格
 

 

 

Cross Reactivity:

Cow, Dog, Monkey, Mouse, Rabbit, Rat, Human, Gelatin Microparticles, N/A

Research Interests:

	Angiogenesis/ Cardiovascular		Apoptosis
	Bone, Skeletal, Cartilage		Proliferation
	Stem Cells & Differentiation		TGF-β Superfamily

 

 

Country of Origin:

USA

Contact Distributor

	Size
A	2μg
B	10μg
	100μg
	250μg
	500μg
	1mg

 

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