Recombinant Human IFN-γ

Catalog Number:

300-02

Synonyms:

Immune Interferon, type II interferon, T cell interferon, MAF

Description:

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ species-specific and is biologically active only in human and primate cells. Recombinant human IFN-γ is a 16.8 kDa protein containing 144 amino acid residues.

AA Sequence:

MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Assay #1: Determined by its ability to induce apoptosis in HeLa cells. The expected ED ₅₀ for this effect is 5.0-10.0 ng/ml.
Assay #2: The ED ₅₀ was determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10 ⁷ units/mg.

厂家促销Recombinant Human IFN-γ 300-02，Peprotech细胞因子价格

Cross Reactivity:

Monkey, Human, Mouse, Leech, Pig, Human + Bacteria, Mandarin Fish, Fish + Virus

Research Interests:

	AIDS / HIV		Angiogenesis/ Cardiovascular
	Cancer		Diabetes / Weight Regulation
	Immune System		Neurobiology
	Stem Cells & Differentiation		Allergy
	Transplantation

Country of Origin:

USA

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