低促销Recombinant Murine IL-10 peprotech210-10细胞因子说明书

 

 

Catalog Number:

210-10

Synonyms:

B-TCGF, CSIF, TGIF

 

 

Description:

IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant murine IL-10 is an 18.7 kDa protein of 161 amino acid residues.

 

 

AA Sequence:

MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGQKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGVYKA MNEFDIFINC IEAYMMIKMK S

 

 

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

 

 

Biological Activity:

PeproTechs murine IL-10 is fully biologically active as measured by the dose-dependent co-stimulation (with IL-4) of the proliferation of murine MC/9 cells. The ED ₅₀ was found to be < 2 ng/ml, corresponding to a specific activity of > 5 x 10 ⁵ units/mg.

 

 

Cross Reactivity:

Human, Mouse, Rat

 

 

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