现货Sigma Pepstatin A胃蛋白酶抑制剂P4265价格

胃蛋白酶抑制剂
中文名： 抑肽素，胃蛋白酶抑制剂
英文名： Pepstatin ， Pepstatin A
PN-Isovaleryl-L-valyl-L-valyl-3-hydroxy-6-methyl-gamma-aminoheptanoyl-L-alanyl-3-hydroxy-
6-methyl-gamma-aminoheptanoic acid ，
（3S,4S）-3-Hydroxy-4-[[（2S）-2-[[（3S,4S）-3-hydroxy-6-methyl-4-[[（2S）-3-methyl-2-[[（2S）-3-methy
l-2-（3-methylbutanoylamino）butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amin
o]-6-methylheptanoic acid; Pepstatin A
分子式 :C34H63N5O9
分子量 :685.89
Sigma 相关资料如下：
P4265   Sigma   Pepstatin A
microbial, ≥75% （HPLC）
CAS Number:26305-03-3
Linear Formula:C34H63N5O9
Molecular Weight:685.89
Beilstein Registry Number:2201362
EC Number:247-600-0
MDL number:MFCD00060740
PubChem Substance ID:24898519

 
Description
Preparation NotePepstatin can be dissolved at 1 mg/ml in 10% （v/v） acetic acid in methanol （9:1 methanol:acetic acid）. The inclusion of acetic acid may be necessary to dissolve this peptide in methanol or DMSO. It has been dissolved at 1 to 2 mg/ml in ethanol, but heat may be required for complete dissolution. Solutions of Pepstatin A can be heated as high as 60 °C without any decomposition of the peptide.
Stock solutions at 1 mg/ml are stable at least a week at 4 °C. A 1 mM solution in methanol or DMSO is stable for months at -20 °C. If solutions become darker yellow, the reagent is hydrolyzing.
A working concentration of 1 μM is stable for at least one day at room temperature.
Biochem/physiol ActionsPepstatin A is an inhibitor of acid proteases （aspartyl peptidases）. It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B （Aspergillus niger）. The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases. Solubilized γ-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources.

 
性质
biological sourcemicrobial
assay≥75% （HPLC）
mp233 °C （dec.）（lit.）
storage temp.2-8°C

 
安全性
Personal Protective EquipmentEyeshields, Gloves, type N95 （US）, type P1 （EN143） respirator filter
Safety Statements22-24/25
WGK Germany2
RTECSSC6155000

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