Brefeldin A is a lactone antibiotic originating discovered in fungi capable of inhibiting protein transport from the endolasmic reticulum to the Golgi apparatus. It is reported to act on the guanine nucleotide exchange factor named GBF1 that mediates the formation of transport vesicles and the unfolded protein response can result in apoptosis in some cells.

Preparation: soluble in organic solvents such as ethanol or DMSO.

溶解性：DMSO 4 mg/mL，水<1 mg/mL，乙醇 <1 mg/mL

稳定性：2年 -20°C粉状，6月-80°C溶于DMSO