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CAS
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1436391-86-4
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英文名称
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PF-06380101
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纯度
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≥98%
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分子式
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C39H62N6O6S
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分子量
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743.01
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外观（性状）
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Solid
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储存条件
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Powder:2-8℃，2years;Insolvent(母液):-20℃，1month;-80℃，6months
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溶解性
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Soluble in DMSO ≥5mg/mL
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描述
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是一种微管抑制剂，具有强细胞毒性。(It is a microtubule inhibitor with strong cytotoxicity.)
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靶点
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Microtubule/Tubulin
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通路
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Cytoskeleton
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规格
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5mg
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单位
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瓶
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中文名称：化合物 T16490
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英文名称：1436391-86-4
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CAS No.：1436391-86-4
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分子式：C39H62N6O6S同分异构体
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分子量：743.021
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类别：生化与分子生物试剂 信号分子 其它化学品
中文别名
2-甲基丙基-N-[(1S,2R)-2-甲氧基-4-[(2S)-2-[(1R,2R)-1-甲氧基-2-甲基-3-氧代-3-[[(1S)-2-苯基-1-(2-噻唑基)乙基]氨基]丙基]-1-吡咯烷基]-1-[(1S)-1-甲基丙基]-4-氧丁基]-N-甲基-1-缬氨酸DOLASTATIN 10类似物
英文别名
(2S)-2-[(2-amino-2-methylpropanoyl)amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamideAuristatin-0101L-Valinamide, 2-methylalanyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-Aur0101PF-063801012-?methylalanyl-?N-?[(1S,?2R)?-?2-?methoxy-?4-?[(2S)?-?2-?[(1R,?2R)?-?1-?methoxy-?2-?methyl-?3-?oxo-?3-?[[(1S)?-?2-?phenyl-?1-?(2-?thiazolyl)?ethyl]?amino]?propyl]?-?1-?pyrrolidinyl]?-?1-?[(1S)?-?1-?methylpropyl]?-?4-?oxobutyl]?-?N-?methyl-L-?ValinamideL-Valinamide, 2-methyl-L-alanyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl ]-N-methyl-2-Methyl-L-alanyl-N-[(3R,4S,5S)-3-methoxy-1-{(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]-1-pyrrolidinyl}-5-methyl-1-oxo-4-heptanyl]-N-methyl-L-va linamide2-Methyl-L-Alanyl-N-[(3r,4s,5s)-3-Methoxy-1-{(2s)-2-[(1r,2r)-1-Methoxy-2-Methyl-3-Oxo-3-{[(1s)-2-Phenyl-1-(1,3-Thiazol-2-Yl)ethyl]amino}propyl]pyrrolidin-1-Yl}-5-Methyl-1-Oxoheptan-4-Yl]-N-Methyl-L-Valinamide3WD
CAS
1436391-86-4
Inchi
InChI=1S/C39H62N6O6S/c1-11-25(4)33(44(8)37(48)32(24(2)3)43-38(49)39(6,7)40)30(50-9)23-31(46)45-20-15-18-29(45)34(51-10)26(5)35(47)42-28(36-41-19-21-52-36)22-27-16-13-12-14-17-27/h12-14,16-17,19,21,24-26,28-30,32-34H,11,15,18,20,22-23,40H2,1-10H3,(H,42,47)(H,43,49)/t25-,26+,28-,29-,30+,32-,33-,34+/m0/s1
InChIkey
QAAFNSMAIAVCHE-BZLYQNAUSA-N
Canonical Smiles
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)C(C)(C)N
国际化联命名
(2S)-2-[(2-amino-2-methylpropanoyl)amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide
