|
CAS
|
843663-66-1
|
|
中文名称
|
贝达喹啉
|
|
英文名称
|
Bedaquiline
|
|
别名
|
TMC-207
|
|
纯度
|
≥98%
|
|
分子式
|
C32H31BrN2O2
|
|
分子量
|
555.5
|
|
外观（性状）
|
White to yellow Solid
|
|
储存条件
|
Powder : -20℃, 2 years;In solvent(母液): -20℃, 1 month; -80℃, 6 months
|
|
溶解性
|
Soluble in DMSO
|
|
MDL
|
MFCD03095271
|
|
EC
|
EINECS 1308068-626-2
|
|
SMILES
|
BrC1=CC=C(N=C(OC)C([C@H]([C@@](C2=CC=CC3=C2C=CC=C3)(O)CCN(C)C)C4=CC=CC=C4)=C5)C5=C1
|
|
描述
|
Bedaquiline是一种二芳基喹啉抗生素,可抑制分枝杆菌ATP合成酶。(Bedaquiline is a diarylquinoline antibiotic that inhibits mycobacterial ATP synthase.)
|
|
靶点
|
Bacterial
|
|
通路
|
Anti-infection
|
|
生物活性
|
Bedaquiline是一种二芳基喹啉抗生素，可抑制分枝杆菌ATP合成酶。[1-3]
|
|
In Vitro
|
Bedaquiline具有优异的抗结核分枝杆菌的体外活性，包括多药耐药的结核分枝杆菌[3]。
|
|
数据来源文献
|
[1]. Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Apr 20.
[2]. Pang Y, et al. In Vitro Activity of Bedaquiline against Nontuberculous Mycobacteria in China. Antimicrob Agents Chemother. 2017 Apr 24;61(5).
[3]. Chahine EB, et al. Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis. Ann Pharmacother. 2014 Jan;48(1):107-15.
|
|
规格
|
5mg 10mg
|
|
单位
|
瓶
|
