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CAS
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29342-05-0
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中文名称
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环吡酮胺
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英文名称
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Ciclopirox
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别名
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环匹罗司;环匹罗司胺
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纯度
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≥98%
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分子式
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C12H17NO2
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分子量
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207.27
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外观（性状）
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White to light yellow Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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EC
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EINECS 249-577-2
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MDL
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MFCD00599441
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InChIKey
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SCKYRAXSEDYPSA-UHFFFAOYSA-N
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InChI
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InChI=1S/C12H17NO2/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10/h7-8,10,15H,2-6H2,1H3
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PubChem CID
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2749
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SMILES
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CC(C=C(C1CCCCC1)N2O)=CC2=O
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描述
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(Ciclopirox is an antifungal compound.)
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靶点
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Fungal
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通路
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Anti-infection
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In Vitro
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In a study conducted to further elucidate Ciclopirox's mechanism, several Saccharomyces cerevisiae mutants were screened and tested. Results from interpretation of the effects of both the drug treatment and mutation suggested that Ciclopirox may exert its effect by disrupting DNA repair, cell division signals and structures (mitotic spindles) as well as some elements of intracellular transport[2].
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数据来源文献
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[1]. Niewerth, M., et al., Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors. Antimicrob Agents Chemother, 2003. 47(6): p. 1805-17.
[2]. Leem, S.H., et al., The possible mechanism of action of ciclopirox olamine in the yeast Saccharomyces cerevisiae. Mol Cells, 2003. 15(1): p. 55-61.
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规格
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25mg 50mg 100mg
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单位
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瓶
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