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CAS
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52152-93-9
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中文名称
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头孢磺啶钠
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英文名称
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Cefsulodin Sodium
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别名
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头孢磺吡苄钠盐
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纯度
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HPLC≥95%
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分子式
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C22H19N4O8S2·Na
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分子量
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554.53
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外观（性状）
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Off white to yellow Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in Water ≥ 50mg/mL
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EC
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EINECS 257-692-4
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MDL
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MFCD07793338
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SMILES
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O=C(N[C@H]1[C@@]2([H])SCC(C[N+]3=CC=C(C(N)=O)C=C3)=C(C([O-])=O)N2C1=O)[C@@H](C4=CC=CC=C4)S(=O)([O-])=O.[Na+]
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描述
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是一种β内酰胺抗生素, 属第三代头孢菌素。(It is a beta-lactam antibiotic, a third-generation cephalosporin.)
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靶点
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Bacterial
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通路
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Anti-infection
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生物活性
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Cefsulodin (Sulcephalosporin) is a β-lactam antibiotic and inhibits mPTPB with the IC50 of 16 μM.[1]
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In Vitro
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Cefsulodin is a third generation β-lactam cephalosporin antibiotic, as a novel pTyr pharmacophore for mPTPB. Cefsulodin has also been found to exhibit inhibitory activity against SHP2 and PTP1B[1].
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In Vivo
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Cefsulodin shows maximum plasma and tissue levels 15-30 minutes after administration of a single dose of 20 mg/kg. In mice, the renal level of cefsulodin is slightly lower than the plasma level, and in rats and dogs, the renal level of cefsulodin is higher than the plasma level. The concentration of cefsulodin in the lung is relatively high in rats and dogs. On the other hand, the hepatic level is very low in all test animal species. The main route of excretion of cefsulodin is the urinary tract. About 80% of cefsulodin is excreted into the urine[3].
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动物实验
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Animal Models: SLC-ddY mice, JCL-Sprague Dawly rats, mongrel dogs; Dosages: 20 mg/kg; Administration: s.c.[2]
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数据来源文献
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[1] He R, et al. ACS Med Chem Lett. 2015, 6(12):1231-5.
[2] Tsuchiya K, et al. J Antibiot (Tokyo). 1978, 31(6):593-7.
[3] Tsuchiya K, et al. J Antibiot (Tokyo). 1978, 31(6):593-7.
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规格
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25mg 50mg
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单位
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瓶
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