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CAS
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101827-46-7
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中文名称
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盐酸布替萘芬
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英文名称
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Butenafine Hydrochloride
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别名
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盐酸丁萘芬；KP-363
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纯度
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≥98%
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分子式
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C23H27N·HCl
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分子量
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353.19
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : -20℃, 2 years;In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO ≥5mg/mL(Need ultrasonic)
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EC
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EINECS 642-354-4
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MDL
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MFCD00917064
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SMILES
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CN(CC1=CC=C(C(C)(C)C)C=C1)CC2=C3C=CC=CC3=CC=C2.[H]Cl
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描述
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是一种苄胺类药物,通过抑制甾醇合成,通过抑制角鲨烯环氧酶,而发挥作用。(It is a benzylamine antifungal drug, which works by inhibiting sterol synthesis and squalene epoxidase.)
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靶点
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Fungal
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通路
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Anti-infection
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生物活性
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Butenafine hydrochloride, N-4-tert-butylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride (butenafine), is a novel antifungal agent of the class of benzylamine derivatives. [1]
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In Vivo
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The concentrations of butenafine in animal skin at 24 and 48 h after application of 0.2 ml of a 1% solution were several hundred times higher than those required to kill T. mentagrophytes and M. canis. The good efficacy of butenafine against dermatophytosis may be attributable to its fungicidal activity and long retention in the skin after topical application.[1]
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数据来源文献
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[1]. Arika T, Yokoo M, Hase T, Maeda T, Amemiya K, Yamaguchi H. Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs. Antimicrob Agents Chemother. 1990 Nov;34(11):2250-3.
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规格
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500mg
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单位
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瓶
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