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CAS
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188062-50-2
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中文名称
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硫酸阿巴卡韦
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英文名称
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Abacavir Sulfate
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别名
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阿巴卡韦硫酸盐；赛进
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纯度
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≥98%
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分子式
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C28H36N12O2·H2SO4
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分子量
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670.74
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : -20℃, 2 years;In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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EC
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EINECS 620-488-4
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MDL
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MFCD04112763
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SMILES
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NC1=NC(NC2CC2)=C3N=CN([C@H]4C=C[C@@H](CO)C4)C3=N1.O=S(O)(O)=O.NC5=NC(NC6CC6)=C7N=CN([C@H]8C=C[C@@H](CO)C8)C7=N5
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描述
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是核苷类似物逆转录酶抑制剂(NRTI),可用于HIV和AIDS的相关研究。(It is a nucleoside analog reverse transcriptase inhibitor (NRTI), which can be used for HIV and AIDS related research.)
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靶点
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Reverse Transcriptase
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通路
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Anti-infection
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生物活性
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Abacavir is a nucleoside reverse transcriptase inhibitor marketed the treatment of infection with the human immunodeficiency virus type 1 (HIV). [1] Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside analogue. It is metabolised intracellularly to a 2'-deoxyguanosine nucleoside analogue which competitively inhibits HIV reverse transcriptase and terminates proviral DNA chain extension. [2]
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数据来源文献
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[1]. Charneira C, et al. Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity. Chem Res Toxicol. 2011 Dec 19;24(12):2129-41.
[2]. Hervey PS, et al. Abacavir: a review of its clinical potential in patients with HIV infection. Drugs. 2000 Aug;60(2):447-79.
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规格
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10mg
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单位
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瓶
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