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CAS
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773-76-2
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中文名称
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5,7-二氯-8-羟基喹啉
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英文名称
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5,7-Dichloro-8-Hydroxyquinoline
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别名
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氯碘羟喹EP杂质 B；Capitrol
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纯度
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≥98%
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分子式
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C9H5Cl2NO
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分子量
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214.05
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外观（性状）
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Light brown to brown Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO ≥5mg/mL;Soluble in Water < 1mg/mL
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EC
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EINECS 212-258-3
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MDL
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MFCD00006786
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InChIKey
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WDFKMLRRRCGAKS-UHFFFAOYSA-N
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InChI
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InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
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PubChem CID
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2722
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SMILES
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OC1=C2N=CC=CC2=C(Cl)C=C1Cl
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描述
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5,7-Dichloro-8-Hydroxyquinoline是一种 化合物。(5,7-Dichloro-8-Hydroxyquinoline is an antibacterial compound.)
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靶点
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Bacterial
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通路
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Anti-infection
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生物活性
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Chloroxine is one of the important 8-hydroxyquinoline derivative. Chloroxine has effective antibacterial， antifungal， antiprotozoal and antiamoebic activities， especially used in treating the intestinal amebiasis. Chloroxine is also used in the treatment of dandruff and seborrheic dermatitis of the scalp[1-2].
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In Vitro
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By using the Jouyban-Acree model， the Chloroxine solubility is well correlated obtaining RAD values lower than 3.64% and RMSD values lower than 8.82?×?10?6. Chloroxine is preferentially solvated by water for the studied mixtures in water-rich compositions; while within intermediate and co-solvent-rich compositions， Chloroxine is preferentially solvated by DMSO (DMF， NMP or 1，4-dioxane) in DMSO (DMF， NMP or 1，4-dioxane)?+?water mixtures. It is shown that the change in solvent-solvent interaction energy accounted by cavity term governed the solubility variation of Chloroxine in all aqueous mixtures[1].
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数据来源文献
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[1]. Renjie X, et al. Solubility modelling, solvent effect and preferential solvation of carbendazim in aqueous co-solvent mixtures of, N,N -dimethylformamide, methanol, ethanol and, n -propanol. J. Chem. Thermodynamics 138 (2019) 288–296.
[2]. Chloroxine (Topical). Dec 27, 2018
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规格
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50mg 100mg 200mg 500mg
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单位
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瓶
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