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CAS
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229975-97-7
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中文名称
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硫酸阿扎那韦
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英文名称
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Atazanavir sulfate
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别名
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BMS-232632 sulfate;西洛司特;阿扎那韦硫酸盐;AtazanavirBisulfateSalt
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纯度
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HPLC≥99%
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分子式
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C38H52N6O7·H2SO4
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分子量
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802.93
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外观（性状）
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White to yellow Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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MDL
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MFCD08067748
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EC
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EINECS 620-495-2
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SMILES
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O=C(OC)N[C@@H](C(C)(C)C)C(NN(CC1=CC=C(C2=NC=CC=C2)C=C1)C[C@H](O)[C@H](CC3=CC=CC=C3)NC([C@H](C(C)(C)C)NC(OC)=O)=O)=O.O=S(O)(O)=O
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描述
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是HIV-1蛋白酶高活性抑制剂。(It is a highly active inhibitor of HIV-1 protease.)
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靶点
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HIV
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通路
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Anti-infection
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生物活性
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BMS-232632 is an azapeptide human immunodeficiency virus type 1 (HIV-1) protease (Prt) inhibitor that exhibits potent anti-HIV activity with a 50% effective concentration (EC(50)) of 2.6 to 5.3 nM and an EC(90) of 9 to 15 nM in cell culture. [1]
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In Vitro
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BMS-232632 blocks the cleavage of viral precursor proteins in HIV-infected cells, proving that it functions as an HIV Prt inhibitor. Comparative studies showed that BMS-232632 is generally more potent than the five currently approved HIV-1 Prt inhibitors. Furthermore, BMS-232632 is highly selective for HIV-1 Prt and exhibits cytotoxicity only at concentrations 6,500- to 23, 000-fold higher than that required for anti-HIV activity. [1]
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数据来源文献
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[1] Robinson BS, et al. Antimicrob Agents Chemother, 2000, 44(8), 2093-2099.
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规格
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10mg 50mg 100mg
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单位
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瓶
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