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CAS
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15686-71-2
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中文名称
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头孢氨苄
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英文名称
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Cefalexin
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别名
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苯甘头孢霉素;Sintolexyn
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纯度
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≥98%
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分子式
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C16H17N3O4S
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分子量
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347.39
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外观（性状）
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White to yellow Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in Water
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MDL
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MFCD04966776
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EC
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EINECS 239-773-6
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InChIKey
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ZAIPMKNFIOOWCQ-UEKVPHQBSA-N
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InChI
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InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
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PubChem CID
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27447
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SMILES
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O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC([C@H](N)C3=CC=CC=C3)=O)C1=O)O
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描述
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Cefalexin是头孢菌素类抗生素。(Cefalexin is a cephalosporin antibiotic.)
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靶点
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Bacterial
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通路
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Anti-infection
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生物活性
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Cephalexin is a potent, orally active and the first-generation cephalosporin antibiotic. Cephalexin kills gram-positive and some gram-negative bacteria by disrupting the growth of the bacterial cell wall[1-2].
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In Vivo
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After a single intravenous administration of cephalexin (5 mg/kg), Mate1(-/-) mice showed higher plasma concentrations of cephalexin than wild-type [Mate1(+/+)] mice. The urinary excretion of cephalexin for 60 min was significantly reduced, and the renal concentration was markedly increased in Mate1(-/-) mice compared with Mate1(+/+) mice. The renal clearance of cephalexin in Mate1(-/-) mice was approximately 60% of that in Mate1(+/+) mice and seemed to be near the creatinine clearance.[1] Cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands, and inhibits the activity of cervix mucous cells. A simultaneous administration of ethanol and cephalexin causes atrophic changes in gastric glands, and thereby strong reduction of mucous cells activity.[2]
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动物实验
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The Wistar rat males weighing approximately 200 g were administered 20% ethanol ad libitum during 10 days, cephalexin in the dose of 42 mg/24 h, and simultaneously ethanol and cephalexin in the above-mentioned doses. After 10 days the animals were decapitated and stomach specimens were taken from the major curvature region for examinations. [2]
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数据来源文献
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[1] Watanabe S, et al. J Pharmacol Exp Ther, 2010, 334(2), 651-656.
[2] Zarebska A, et al. Ann Univ Mariae Curie Sklodowska Med, 2004, 59(1), 145-150.
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规格
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500mg 1g 5g
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单位
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瓶
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