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CAS
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549-18-8
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中文名称
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盐酸阿米替林
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英文名称
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Amitriptyline Hydrochloride
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别名
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Annoyltin;Tryptizol;Domical
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纯度
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HPLC≥98%
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分子式
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C20H23N·HCl
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分子量
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313.87
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外观（性状）
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White to yellow Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in Water/DMSO
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MDL
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MFCD00012537
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EC
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EINECS 208-964-6
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InChIKey
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KFYRPLNVJVHZGT-UHFFFAOYSA-N
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InChI
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InChI=1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
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PubChem CID
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11065
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SMILES
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CN(C)CC/C=C1C2=CC=CC=C2CCC3=C\1C=CC=C3.Cl
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描述
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是一种SERT和NET抑制剂,还与DAT结合,也抑制Adrenergic receptor、mAChR、Histamine receptor和5-HT receptor。此外，还是一种具有强神经营养活性的TrkA和TrkA受体激动剂。(It is a SERT and NET inhibitor. It also binds to DAT and also inhibits Adrenergic receptor, mAChR, Histamine receptor and 5-HT receptor. In addition, it is a TrkA and TrkA receptor agonist with strong neurotrophic activity.)
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靶点
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SERT;NET;DAT;Adrenergic receptor;mAChR;Histamine receptor;5-HT receptor;TrkA
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通路
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Neuronal Signaling;Membrane Transporter&Ion Channel;Endocrinology & Hormones;GPCR & G Protein；Immunology & Inflammation
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