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CAS
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1617-53-4
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中文名称
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穗花杉双黄酮
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英文名称
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Amentoflavone
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别名
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阿曼托黄酮; Didemethyl-ginkgetin
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纯度
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HPLC≥98%
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分子式
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C30H18O10
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分子量
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538.46
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外观（性状）
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Light yellow to yellow-green Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO ≥10mg/mL
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MDL
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MFCD00017470
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InChIKey
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YUSWMAULDXZHPY-UHFFFAOYSA-N
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InChI
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InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H
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PubChem CID
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5281600
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SMILES
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O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4O)C(O)=CC(O)=C13
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描述
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是一种双黄酮类化合物,具有很多生物活性,抗氧化、神经保护等作用。(It is a biflavonoid compound with many biological activities, including anti-inflammatory, antioxidant, neuroprotective and other effects.)
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靶点
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Reactive oxygen species (ROS)
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通路
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Immunology & Inflammation
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生物活性
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Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.[1-2]
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In Vitro
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Amentoflavone induces morphological changes and reduces the percentage of viable MCF-7 cells. Amentoflavone induces apoptosis and chromatin condensation, DNA strand breaks in MCF-7 cells. Amentoflavone is also reported to induce cell-cycle arrest at the sub-G1 phase, and apoptosis via mitochondria-emanated intrinsic pathways in SiHa and CaSki human cervical cancer cells[1].
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In Vivo
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In an animal model, amentoflavone is found to significantly inhibit B16F-10 melanoma-induced solid tumor development in C57BL/6 mice[1]. Amentoflavone can cross the blood-brain barrier. It effectively prevents pilocarpine-induced epilepsy in a mouse kindling model, suppresses NF-kB activation and expression, inhibits excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons[2].
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细胞实验
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Approximately 2×105 MCF-7 cells/well in 24-well plates are treated with 250 μM amentoflavone, or with vehicle (DMSO, 0.1% in culture media)-only and all cells are incubated for 6 to 72 h. For the examination of morphological changes, cells are photographed under a phase-contrast microscope.[1]
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动物实验
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Animal Models: Kunming mice;Dosages: 25 mg/kg;Administration: intragastrically administered[2]
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数据来源文献
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[1] Pei JS, et al. In Vivo. 2012, 26(6):963-70.
[2] Zhang Z, et al. Neural Regen Res. 2015, 10(7):1125-33.
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规格
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5mg 10mg 10mM*1mL (in DMSO)
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单位
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瓶
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