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CAS
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481-72-1
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中文名称
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芦荟大黄素
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英文名称
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Aloe emodin
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别名
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3-Hydroxymethylchrysazine;Rhabarberone;NSC 38628
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纯度
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HPLC≥98%
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分子式
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C15H10O5
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分子量
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270.24
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外观（性状）
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Yellow to orange Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO ≥5mg/mL
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MDL
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MFCD00017373
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EC
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EINECS 207-571-7
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InChIKey
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YDQWDHRMZQUTBA-UHFFFAOYSA-N
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InChI
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InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
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PubChem CID
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10207
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SMILES
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O=C1C2=C(C=CC=C2O)C(C3=CC(CO)=CC(O)=C13)=O
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描述
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Aloe emodin是从芦荟叶中提取的羟基蒽醌(Aloe emodin is a hydroxyanthraquinone extracted from aloe vera leaves and has been shown to have antitumor activity both in vitro and in vivo.)
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靶点
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Others
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通路
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Others
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生物活性
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Aloe emodin is a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antitumor activity.[1]
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In Vitro
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Aloe-emodin treatment led to the dissociation of heat shock protein 90 (HSP90) and ER α and increased ER α ubiquitination. Protein fractionation results suggest that aloe-emodin tended to induce cytosolic ER α degradation [1].
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激酶实验
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Protein content analysis suggested that activation of the downstream substrates of mTORC2, Akt and PKCα, was inhibited by aloe-emodin treatment. Pull-down assay and in vitro kinase assay results indicated that aloe-emodin could bind with mTORC2 in cells and inhibit its kinase activity [2].
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数据来源文献
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[1]. Huang PH, et al. Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition. Evid Based Complement Alternat Med. 2013;2013:376123.
[2]. Liu K, et al. Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. Carcinogenesis. 2012 Jul;33(7):1406-11.
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规格
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10mg 10mM*1mL in DMSO 50mg 100mg
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单位
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瓶
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