|
CAS
|
344423-98-9
|
|
中文名称
|
阿托伐他汀钙三水
|
|
英文名称
|
Atorvastatin Hemicalcium Salt Trihydrate
|
|
别名
|
阿托伐他汀钙三水合物, 阿托伐他汀钙水合物, atorvastatin calcium trihydrate, Atorvastatin hemicalcium salt sesquihydrate, atorvastatin calcium trihydrate
|
|
纯度
|
HPLC≥98%
|
|
分子式
|
2(C33H34FN2O5)·Ca·3(H2O)
|
|
分子量
|
1209.4
|
|
外观（性状）
|
White to off-white Solid
|
|
储存条件
|
Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
|
|
溶解性
|
Soluble in DMSO ≥20mg/mL
|
|
MDL
|
MFCD03613598
|
|
EC
|
EINECS 200-659-6
|
|
InChIKey
|
SHZPNDRIDUBNMH-NIJVSVLQSA-L
|
|
InChI
|
InChI=1S/2C33H35FN2O5.Ca.3H2O/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);;3*1H2/q;;+2;;;/p-2/t2*26-,27-;;;;/m11..../s1
|
|
PubChem CID
|
656846
|
|
SMILES
|
FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C(C(C)C)N2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C=C1.[0.5Ca2+]
|
|
描述
|
Atorvastatin hemicalcium salt 是有效的 HMG-CoA 还原酶抑制剂。(Atorvastatin hemicalcium salt is a potent HMG-CoA reductase inhibitor.)
|
|
靶点
|
HMG-CoA Reductase (HMGCR)
|
|
通路
|
Metabolic Enzyme&Protease
|
|
生物活性
|
Atorvastatin calcium trihydrate is a potent and selective inhibitor of HMG-CoA reductase primarily used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin is used primarily for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. As with all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.[1]
|
|
数据来源文献
|
[1]J Clin Invest. 1998 Jun 15;101(12):2711-9; Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H457-66.
|
|
规格
|
10mg 10mM*1mL (in DMSO) 50mg
|
|
单位
|
瓶
|
