|
CAS
|
22839-47-0
|
|
中文名称
|
阿斯巴甜
|
|
英文名称
|
Aspartame
|
|
别名
|
阿司帕坦; N-L-alpha-天冬氨酰基-L-苯丙氨酸甲酯
|
|
纯度
|
HPLC≥99%
|
|
分子式
|
C14H18N2O5
|
|
分子量
|
294.3
|
|
外观（性状）
|
White to off-white Solid
|
|
储存条件
|
Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
|
|
溶解性
|
Soluble in Water/DMSO
|
|
MDL
|
MFCD00002724
|
|
EC
|
EINECS 245-261-3
|
|
InChIKey
|
IAOZJIPTCAWIRG-QWRGUYRKSA-N
|
|
InChI
|
InChI=1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1
|
|
PubChem CID
|
134601
|
|
SMILES
|
O=C(OC)[C@@H](NC([C@@H](N)CC(O)=O)=O)CC1=CC=CC=C1
|
|
描述
|
Aspartame是一种非糖类甜味剂。(Aspartame is a non-sugar sweetener.)
|
|
靶点
|
Others
|
|
通路
|
Others
|
|
生物活性
|
Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1-2].
|
|
In Vitro
|
Aspartame is composed of phenylalanine (an important role in neurotransmitter regulation), aspartic acid (an excitatory neurotransmitter in the central nervous system) and methanol[2].
|
|
In Vivo
|
Aspartame (4000 mg/kg bw/day; p.o.) shows no adverse effect in acute, subacute and chronic toxicity studies with aspartame, and its decomposition products, conducted in mice, rats, hamsters and dogs[1].
|
|
数据来源文献
|
[1]. Magnuson BA, et, al. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol. 2007;37(8):629-727.
[2]. Humphries P, et, al. Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr. 2008 Apr;62(4):451-62.
|
|
规格
|
50mg 100mg 10mM*1mL (in DMSO)
|
|
单位
|
瓶
|
