|
CAS
|
497-76-7
|
|
中文名称
|
熊果苷
|
|
英文名称
|
Arbutin
|
|
别名
|
β-Arbutin;Uva
|
|
纯度
|
HPLC≥98%
|
|
分子式
|
C12H16O7
|
|
分子量
|
272.25
|
|
外观（性状）
|
White to off-white Solid
|
|
储存条件
|
Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
|
|
溶解性
|
Soluble in Water/DMSO
|
|
MDL
|
MFCD00016915
|
|
EC
|
EINECS 207-850-3
|
|
InChIKey
|
BJRNKVDFDLYUGJ-RMPHRYRLSA-N
|
|
InChI
|
InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1
|
|
PubChem CID
|
440936
|
|
SMILES
|
O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(O)C=C2
|
|
描述
|
Arbutin是一种糖苷,可抑制酪氨酸酶,阻止黑色素生成。(Arbutin is a glycoside that inhibits tyrosinase, preventing melanin production.)
|
|
靶点
|
Tyrosinase
|
|
通路
|
Metabolic Enzyme&Protease
|
|
生物活性
|
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[1-3].
|
|
In Vitro
|
Arbutin (0.3-5.4 mM; 24 hours, 48 hours, 72 hours; B16 murine melanoma cells) inhibites the viability of B16 murine melanoma cells in a time-and dose-dependent manner.Arbutin (1.4-5.4 mM; 24 hours) increases the apoptosis rate of B16 murine melanoma cell of treatment at a dose of 5.4 mM[2].
|
|
In Vivo
|
Arbutin (50 mg/kg, 100 mg/kg; oral administration; every day; for 17 days; male C57BL/6 mice) pretreatment exhibits markedly protective effects on ISO-induced cardiac hypertrophy in mice[3].
|
|
数据来源文献
|
[1]. Garcia-Jimenez A, et al. Action of tyrosinase on alpha and beta-arbutin: A kinetic study. PLoS One. 2017 May 11;12(5):e0177330.
[2]. Jiang L, et al. Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murinemelanoma cells. Int J Mol Med. 2018 Feb;41(2):1048-1054.
[3]. Nalban N, et al. Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice. Cardiovasc Toxicol. 2019 Sep 4.
|
|
规格
|
20mg 10mM*1mL (in DMSO) 100mg
|
|
单位
|
瓶
|
