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CAS
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7770-78-7
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中文名称
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牛蒡苷元
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英文名称
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Arctigenin
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别名
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(-)-Arctigenin
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纯度
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HPLC≥98%
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分子式
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C21H24O6
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分子量
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372.41
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : -20℃, 2 years;In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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MDL
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MFCD00870597
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InChIKey
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NQWVSMVXKMHKTF-JKSUJKDBSA-N
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InChI
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InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1
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PubChem CID
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64981
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SMILES
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O=C1OC[C@H](CC2=CC=C(OC)C(OC)=C2)[C@H]1CC3=CC=C(O)C(OC)=C3
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描述
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是一种木酚素(It is a lignan with antiviral and anticancer activity.)
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靶点
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Others
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通路
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Others
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生物活性
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Arctigenin is a phytoestrogen that exerts a proliferative effect by binding to the ER. Arctigenin from Arctium lappa (L.) can both inhibit Aβ production by suppressing β-site amyloid precursor protein cleavage enzyme 1 expression and promote Aβ clearance by enhancing autophagy through AKT/mTOR signaling inhibition and AMPK/Raptor pathway activation as investigated in cells and APP/PS1 transgenic AD model mice. [2-3]
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In Vitro
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MTT and LDH results demonstrated significant cell growth inhibitory effect of arctigenin on HT-29 cells in a dose-dependent manner. Arctigenin induces apoptosis in HT-29 colon cancer cells by regulating ROS and p38 MAPK pathways.[1] It is a phytoestrogen that exerts a proliferative effect by binding to the ER. Treatment with arctigenin effectively downregulates ERα expression. Thus, arctigenin, mainly targets the mTOR pathway in ERα-positive MCF-7 human breast cancer cells, leading to autophagy-induced cell death and the downregulation of ERα expression[2]. Arctigenin decreases BACE1 translation via dephosphorylation of eIF2α, causing the suppression of Aβ production, and initiates autophagy through both AMPK/Raptor signaling activation and AKT/mTOR pathway inhibition, resulting in enhanced Aβ clearance. Arctigenin suppresses BACE1 activity via inhibition of BACE1 translation[3].
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In Vivo
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Treatment of arctigenin in mice highly decreases Aβ formation and senile plaques and efficiently ameliorates AD mouse memory impairment of APP/PS1 transgenic model mice[3].
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数据来源文献
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[1] Li QC, et al. J BUON. 2016, 21(1):87-94.
[2] Maxwell T, et al. Int J Oncol. 2018, 52(4):1339-1349.
[3] Zhu Z, et al. J Neurosci. 2013, 33(32):13138-49.
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规格
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10mg 10mM*1mL (in DMSO) 50mg
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单位
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瓶
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