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CAS
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474-25-9
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中文名称
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鹅去氧胆酸
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英文名称
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Chenodeoxycholic Acid
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别名
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CDCA;Chenodiol
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纯度
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HPLC≥98%
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分子式
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C24H40O4
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分子量
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392.57
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO ≥50mg/mL
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MDL
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MFCD00064142
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EC
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EINECS 207-481-8
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InChIKey
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RUDATBOHQWOJDD-BSWAIDMHSA-N
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InChI
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InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1
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PubChem CID
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10133
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SMILES
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O=C(O)CC[C@@H](C)[C@]1([H])[C@]2(C)[C@](CC1)([H])[C@]3([H])[C@H](O)C[C@@](C4)([H])[C@@](CC[C@H]4O)(C)[C@]([H])3CC2
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描述
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Chenodeoxycholic Acid能够活化核受体 FXR,该受体与胆固醇代谢有关,主要作用是降低胆汁内胆固醇的饱和度,从而使结石中的胆固醇溶解、脱落。(Chenodeoxycholic Acid can activate nuclear receptor FXR, which is related to cholesterol metabolism. The main function is to reduce cholesterol saturation in bile, so as to dissolve and shed cholesterol in stones.)
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靶点
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FXR
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通路
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Metabolic Enzyme&Protease
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生物活性
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Chenodeoxycholic Acid 是一种疏水初级胆汁酸，能够活化核受体 FXR，该受体与胆固醇代谢有关[1-5]。
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