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CAS
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15663-27-1
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中文名称
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顺铂
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英文名称
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Cisplatin
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别名
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顺二氯二氨基铂; ?顺氯氨铂; CIS-PLATIN
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纯度
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HPLC≥98%
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分子式
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Cl2H6N2Pt
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分子量
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300.05
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : 2-8℃, 2 years
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溶解性
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Soluble in DMF(* 建议使用 DMF 而不是 DMSO溶解。* 该产品在溶液状态不稳定,建议您现用现配/*Use DMF instead of DMSO to dissolve.*The product is unstable after dissolution. It is recommended that you use it immediately after dissolution.)
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EC
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EINECS 239-733-8
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MDL
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MFCD00011623
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InChIKey
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DQLATGHUWYMOKM-UHFFFAOYSA-L
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InChI
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InChI=1S/2ClH.2H2N.Pt/h2*1H;2*1H2;/q;;2*-1;+4/p-2
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PubChem CID
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2767
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SMILES
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[Cl-][Pt+2]([Cl-])([NH3])[NH3]
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描述
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Cisplatin与 DNA 交联引起癌细胞中 DNA 损伤Cisplatin可激活铁死亡 (ferroptosis) 并诱导自噬 (autophagy)。(Cisplatin cross-linking with DNA can cause DNA damage in cancer cells and can be used in the research of anti-tumor chemotherapy drugs. Cisplatin can activate ferroptosis and induce autophagy.)
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靶点
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Ferroptosis;DNA Crosslinker
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通路
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Apoptosis
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