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CAS
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14534-61-3
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中文名称
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异绿原酸B
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英文名称
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3,4-Dicaffeoylquinic acid
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别名
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3,4-二咖啡酰奎宁酸
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纯度
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HPLC≥98%
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分子式
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C25H24O12
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分子量
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516.46
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外观（性状）
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Light yellow to yellow Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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MDL
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MFCD08272439
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InChIKey
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UFCLZKMFXSILNL-PSEXTPKNSA-N
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InChI
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InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(35,24(33)34)11-19(30)23(20)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,35H,11-12H2,(H,33,34)/b7-3+,8-4+/t19-,20-,23-,25+/m1/s1
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PubChem CID
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5281780
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SMILES
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O=C([C@@]1(O)C[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)[C@H](OC(/C=C/C3=CC=C(O)C(O)=C3)=O)[C@H](O)C1)O
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描述
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3,4-Dicaffeoylquinic acid具有凋亡介导的细胞毒性(3,4-Dicaffeoylquinic acid has apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects.)
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靶点
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Others
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通路
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Others
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生物活性
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3，4-Dicaffeoylquinic acid (3，4-Di-O-caffeoylquinic acid)， naturally isolated from Laggera alata， has antioxidative， DNA protective， neuroprotective and hepatoprotective properties. 3，4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3，4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity， that is， enhancing viral clearance by increasing TRAIL[1-3].
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In Vitro
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3，4-Dicaffeoylquinic acid acts as a greater primary antioxidant than its methanol extract， by having higher ferric reducing activity (EC50 2.18 μg/ml)， β-carotene bleaching activity (EC50 23.85 μg/ml) and DPPH scavenging activity (EC50 68.91 μg/ml). 3，4-Dicaffeoylquinic acid exhibits a remarkable dose-dependent inhibitory effect on NCI-H23 (human lung adenocarcinoma) cell lines (EC50 3.26 μg/ml) and is found to be apoptotic in nature based on a clear indication of DNA fragmentation. 3，4-Dicaffeoylquinic acid also displays a concentration-dependent α-glucosidase inhibition with EC50 241.80 μg/ml[1].
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数据来源文献
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[1]. Takemura T, et al. 3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus. Evid Based Complement Alternat Med. 2012;2012:946867.
[2]. Liu X, et al. Protective effect of isochlorogenic acid B on liver fibrosis in non-alcoholic steatohepatitis of mice. Basic Clin Pharmacol Toxicol. 2019;124(2):144-153.
[3]. Ooi KL, et al. Cytotoxic, apoptotic and anti-α-glucosidase activities of 3,4-di-O-caffeoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth. J Ethnopharmacol. 2011;135(3):685-695.
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规格
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5mg 10mM*1mL (in DMSO) 10mg
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单位
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瓶
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