|
CAS
|
208255-80-5
|
|
中文名称
|
(2S)-N-[N-(3,5-二氟苯乙酰基)-L-丙氨酰]-2-苯基甘氨酸叔丁酯
|
|
英文名称
|
DAPT
|
|
别名
|
(3,5-二氟苯乙酰基)-Ala-Phg-OtBu; GSIIX; DAPT (GSI-IX)
|
|
纯度
|
HPLC≥98%
|
|
分子式
|
C23H26F2N2O4
|
|
分子量
|
432.46
|
|
外观（性状）
|
White to off-white Solid
|
|
储存条件
|
Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
|
|
溶解性
|
Soluble in DMSO
|
|
MDL
|
MFCD00055267
|
|
InChIKey
|
DWJXYEABWRJFSP-XOBRGWDASA-N
|
|
InChI
|
InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
|
|
PubChem CID
|
5311272
|
|
SMILES
|
FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1
|
|
描述
|
DAPT是一种有效的γ-secretase抑制剂,抑制 Notch 1 信号传导并诱导细胞分化。还可诱导细胞自噬和凋亡。具有神经保护活性。(DAPT is a potent gamma-secretase inhibitor that inhibits Notch 1 signaling and induces cell differentiation. It can also induce autophagy and apoptosis. It has neuroprotective activity.)
|
|
靶点
|
Notch;γ-secretase;Autophagy;Apoptosis
|
|
通路
|
Stem Cells;Neuronal Signaling;Autophagy;Apoptosis;
|
|
生物活性
|
DAPT是 γ-分泌酶 (γ-secretase) 抑制剂，抑制总 Aβ 和 Aβ42 的 IC50 分别为 115 和 200 nM[5]。
|
|
IC50
|
115 nM (Aβ), 200 nM (Aβ42)[5]
|
