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CAS
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27200-12-0
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中文名称
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二氢杨梅素
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英文名称
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Dihydromyricetin
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别名
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(2R,3R)-3,5,7-三羟基-2-(3,4,5-三羟基苯基)苯并二氢吡喃-4-酮; ?蛇葡萄素; Ampelopsin; Ampeloptin; (+)-Ampelopsin
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纯度
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HPLC≥98%
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分子式
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C15H12O8
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分子量
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320.25
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO ≥10mg/mL
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MDL
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MFCD00189451
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EC
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EINECS 200-001-8
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InChIKey
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KJXSIXMJHKAJOD-LSDHHAIUSA-N
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InChI
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InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
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PubChem CID
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161557
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SMILES
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O=C1[C@H](O)[C@@H](C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13
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描述
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是一种有效的二氢嘧啶酶 (dihydropyrimidinase) 抑制剂。Dihydromyricetin 可通过抑制 mTOR 信号从而激活自噬。Dihydromyricetin 抑制 mTOR 复合体 (mTORC1/2) 形成。(It is a potent dihydropyrimidase inhibitor. Dihydromyricetin activates autophagy by inhibiting mTOR signaling. Dihydromyricetin inhibits mTOR complex (mTORC1/2) formation.)
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靶点
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mTOR
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通路
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PI3K/Akt/mTOR
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生物活性
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Dihydromyricetin 是一种有效的二氢嘧啶酶 (dihydropyrimidinase) 抑制剂，IC50 为 48 μM。Dihydromyricetin 可通过抑制 mTOR 信号从而激活自噬。Dihydromyricetin 抑制 mTOR 复合体 (mTORC1/2) 形成。[1-3]
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IC50
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Dihydropyrimidinase:48 μM [1]
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