|
CAS
|
49562-28-9
|
|
中文名称
|
非诺贝特
|
|
英文名称
|
Fenofibrate
|
|
别名
|
Procetofen;Lipanthyl;Lipantil
|
|
纯度
|
≥99%
|
|
分子式
|
C20H21ClO4
|
|
分子量
|
360.83
|
|
外观（性状）
|
White to off-white Solid
|
|
储存条件
|
Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
|
|
溶解性
|
Soluble in DMSO
|
|
MDL
|
MFCD00133314
|
|
EC
|
EINECS 256-376-3
|
|
InChIKey
|
YMTINGFKWWXKFG-UHFFFAOYSA-N
|
|
InChI
|
InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
|
|
PubChem CID
|
3339
|
|
SMILES
|
CC(C)(OC1=CC=C(C(C2=CC=C(Cl)C=C2)=O)C=C1)C(OC(C)C)=O
|
|
描述
|
Fenofibrate是一种选择性的PPARα激动剂。Fenofibrate抑制细胞色素 P450 亚型,例如CYP2C19,CYP2B6,CYP2C9,CYP2C8 和 CYP3A4。(Fenofibrate is a selective PPARα agonist. Fenofibrate inhibits cytochrome P450 isoforms such as CYP2C19, CYP2B6, CYP2C9, CYP2C8 and CYP3A4.)
|
|
靶点
|
PPAR;Cytochrome P450
|
|
通路
|
Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease
|
|
生物活性
|
Fenofibrate是 PPARα 激动剂，EC50 为30 μM。[1-2]
|
|
IC50
|
CYP2C19:0.2 μM ; CYP2B6:0.7 μM [1]
|
