|
CAS
|
68406-26-8
|
|
中文名称
|
人参皂苷Rb3
|
|
英文名称
|
Ginsenoside Rb3
|
|
别名
|
Gypenoside IV
|
|
纯度
|
HPLC≥98%
|
|
分子式
|
C53H90O22
|
|
分子量
|
1079.28
|
|
外观（性状）
|
White to off-white Solid
|
|
储存条件
|
Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
|
|
溶解性
|
Soluble in DMSO
|
|
MDL
|
MFCD10566396
|
|
SMILES
|
C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O[C@@](O[C@H](CO)[C@@H](O)[C@@H]4O)([H])[C@@H]4O[C@]([C@@H]([C@@H](O)[C@@H]5O)O)([H])O[C@@H]5CO)C)(CC[C@@]2([H])C3(C)C)[C@]6([C@@]1([H])[C@]([C@@](CC/C=C(C)/C)(C)O[C@@H]([C@@H]([C@@H](O)[C@@H]7O)O)O[C@@H]7CO[C@H](OC[C@@H](O)[C@@H]8O)[C@@H]8O)([H])CC6)C
|
|
描述
|
据报道,在 293T 细胞系中 Ginsenoside Rb3 抑制 TNFα 诱导的 NF-κB 转录活性,IC50 为 8.2 μM。Ginsenoside Rb3 还抑制 COX-2 和 iNOS mRNA的诱导。(Ginsenoside Rb3 has been reported to inhibit TNFα-induced NF-κB transcriptional activity in 293T cell line with IC50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.)
|
|
靶点
|
NF-kB;COX-2;iNOS
|
|
通路
|
NF-κB;Immunology & Inflammation
|
