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CAS
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303-45-7
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中文名称
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棉酚
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英文名称
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Gossypol
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别名
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棉籽酚;BL 193;Pogosin;NSC 56817
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纯度
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HPLC≥98%
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分子式
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C30H30O8
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分子量
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518.55
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外观（性状）
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Light yellow to yellow Solid
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储存条件
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Powder : 2-8℃, 2 years
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溶解性
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Soluble in DMSO ≥5mg/mL(该产品在溶液状态不稳定,建议您现用现配/The product is unstable after dissolution. It is recommended that you use it immediately after dissolution.)
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MDL
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MFCD00017352
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EC
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EINECS 636-899-7
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InChIKey
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QBKSWRVVCFFDOT-UHFFFAOYSA-N
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InChI
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InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
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PubChem CID
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3503
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SMILES
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O=CC1=C(O)C(O)=C(C(C)C)C2=CC(C)=C(C3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O)C(O)=C12
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描述
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Gossypol是一种 5α-reductase 1 和 3α-hydroxysteroid dehydrogenase 的有效抑制剂。Gossypol 还可抑制BH3肽与Bcl蛋白的结合。(Gossypol is a potent inhibitor of 5 alpha-reductase 1 and 3 alpha-hydroxysteroid dehydrogenase. Gossypol also inhibits the binding of BH3 peptide to Bcl protein.)
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靶点
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Bcl-2 Family;Bcl-xL
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通路
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Apoptosis
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生物活性
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Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively.[1]Gossypol inhibits 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase: Its possible use for the treatment of prostate cancer[2]
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