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| 产地 | 国产 |
| 品牌 | Solarbio |
| 货号 | II0060 |
| 用途 | 抑制剂 |
| 包装规格 | 10mg |
| CAS编号 | 152459-95-5 |
| 纯度 | 98% |
| 是否进口 | 否 |
| CAS | 152459-95-5 |
| 中文名称 | 伊马替尼 |
| 英文名称 | Imatinib |
| 别名 | 甲磺酸伊马替尼 |
| 纯度 | HPLC≥98% |
| 分子式 | C29H31N7O |
| 分子量 | 493.6 |
| 外观（性状） | Off-white to light yellow Solid |
| 储存条件 | Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months |
| 溶解性 | Soluble in DMSO |
| MDL | MFCD05662257 |
| EC | EINECS 604-855-6 |
| InChIKey | KTUFNOKKBVMGRW-UHFFFAOYSA-N |
| InChI | InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) |
| PubChem CID | 5291 |
| SMILES | CN(CC1)CCN1CC2=CC=C(C(NC3=CC=C(C)C(NC4=NC(C5=CC=CN=C5)=CC=N4)=C3)=O)C=C2 |
| 描述 | Imatinib是一种酪氨酸激酶抑制剂,可抑制 c-Kit,Bcr-Abl 和 PDGFR。(Imatinib is a tyrosine kinase inhibitor that inhibits c-Kit, Bcr-Abl and PDGFR.) |
| 靶点 | c-Kit;Bcr-Abl;v-Abl;PDGFR |
| 通路 | Protein Tyrosine Kinase/RTK |
| 生物活性 | Imatinib 是一种酪氨酸激酶抑制剂，可抑制 c-Kit，Bcr-Abl 和 PDGFR。[1-6] |
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| 数据来源文献 |
[1]. Heinrich MC, et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood. 2000 Aug 1; 96 (3) :925-32. [2]. Guida T, et al. Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants. Clin Cancer Res. 2007 Jun 1; 13 (11) :3363-9. [3]. Okuda K, et al. ARG tyrosine kinase activity is inhibited by STI571.Blood. 2001 Apr 15; 97 (8) :2440-8 [4]. Yao JC, et al. Clinical and in vitro studies of imatinib in advanced carcinoid tumors. Clin Cancer Res. 2007 Jan 1; 13 (1) :234-40. [5]. Sun XC, et al. Depletion of telomerase RNA inhibits growth of gastrointestinal tumors transplanted in mice. World J Gastroenterol. 2013 Apr 21; 19 (15) :2340-7. [6]. Yildiz C, et al. Effect of imatinib on growth of experimental endometriosis in rats. Eur J Obstet Gynecol Reprod Biol. 2016 Feb; 197:159-63 |
| Note | 以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。These protocols are for reference only. Solarbio does not independently validate these methods. |
| 规格 | 10mg 10mM*1mL (in DMSO) 50mg |
| 单位 | 瓶 |
