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CAS
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19685-09-7
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中文名称
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10-羟基喜树碱
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英文名称
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(S)-10-Hydroxycamptothecin
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别名
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羟基喜树碱; 10-Hydroxy camptothecin; 10-OH-camptothecin; 10-hydroxy-CPT
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纯度
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HPLC≥98%
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分子式
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C20H16N2O5
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分子量
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364.35
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外观（性状）
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Light yellow to yellow Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO ≥10mg/mL
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MDL
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MFCD02093100
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EC
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EINECS 805-668-4
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InChIKey
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HAWSQZCWOQZXHI-FQEVSTJZSA-N
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InChI
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InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
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PubChem CID
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97226
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SMILES
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O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=CC(O)=CC=C5N=C4C3=C2)=O
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描述
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((S)-10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor. Can significantly induce apoptosis, and can be used for the study of liver cancer, gastric cancer, colon cancer and leukemia.)
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靶点
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Topoisomerase
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通路
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DNA Damage/DNA Repair
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生物活性
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(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma， gastric carcinoma， colon cancer and leukaemia treatment[1-3].
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In Vitro
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(S)-10-Hydroxycamptothecin inhibits L1210 leukemia cells with an IC50 of 1.15 μM[1].(S)-10-Hydroxycamptothecin (5-20 μg/L; 6 days; Hep G2 cells) treatment results in the cell cycle arrest at G2/M phase[2].(S)-10-Hydroxycamptothecin induces differentiation， down-regulates nuclear antigen (PCNA) and up-regulates wild-type protein p53 in Hep G2 cells[2].
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In Vivo
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(S)-10-Hydroxycamptothecin (10-Hydroxycamptothecin) against L1210 leukemia in mice is tested. At the optimal dose (15 mg/kg)， (S)-10-Hydroxycamptothecin has a 71% increase in life span (ILS)[1].
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数据来源文献
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[1]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance . Journal of Drug Targeting.
[2]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target, Early Online: 1–8
[3]. Yu P, et al. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol Pharm Bull. 2012;35(8):1295-9.
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规格
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5mg 10mg 10mM*1mL (in DMSO)
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单位
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瓶
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