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CAS
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69-09-0
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中文名称
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氯丙嗪盐酸盐
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英文名称
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Chlorpromazine Hydrochloride
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别名
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Sonazine
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纯度
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HPLC≥98%
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分子式
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C17H19ClN2S·HCl
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分子量
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355.33
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : 2-8℃, 2 years
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溶解性
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Soluble in Water/DMSO(该产品在溶液状态不稳定,建议您现用现配/The product is unstable after dissolution. It is recommended that you use it immediately after dissolution.)
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MDL
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MFCD00012654
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EC
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EINECS 200-701-3
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InChIKey
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FBSMERQALIEGJT-UHFFFAOYSA-N
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InChI
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InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
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PubChem CID
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6240
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SMILES
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CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13.Cl
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描述
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Chlorpromazine Hydrochloride是D2,5HT2A,钾通道和钠通道的拮抗剂。(Chlorpromazine Hydrochloride is an antagonist of D2, 5HT2A, potassium channels and sodium channels.)
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靶点
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Dopamine Receptor; 5-HT Receptor; Sodium Channel; Potassium Channel
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通路
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GPCR/G Protein; Neuronal Signaling; Membrane Transporter/Ion Channel
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生物活性
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Chlorpromazine Hydrochloride是D2，5HT2A，钾通道和钠通道的拮抗剂。 Chlorpromazine与 D2 和 5HT2A 结合的 Ki 分别为363 nM和8.3 nM。[1-5]
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IC50
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Ki: 363 nM (dopamine D2 receptor), 8.3 nM (5-HT2A receptor)[4]
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