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CAS
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50-23-7
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中文名称
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氢化可的松
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英文名称
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Hydrocortisone
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别名
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Cortisol
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纯度
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HPLC≥98%
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分子式
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C21H30O5
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分子量
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362.46
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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MDL
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MFCD00011654
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EC
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EINECS 200-020-1
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InChIKey
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JYGXADMDTFJGBT-VWUMJDOOSA-N
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InChI
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InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
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PubChem CID
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5754
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SMILES
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C[C@@]1([C@@]2(O)C(CO)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])[C@@H](O)C1
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描述
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(Hydrocortisone is a glucocorticoid receptor agonist that promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses.)
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靶点
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Glucocorticoid Receptor (GR, or GCR)
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通路
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GPCR & G Protein
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生物活性
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Hydrocortisone是肾上腺皮质分泌的类固醇激素或糖皮质激素。[1-3]
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细胞实验
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将细胞接种在胶原蛋白IV涂覆的transwell小室顶部，用于六孔板（直径24mm，膜材料：聚对苯二甲酸乙二醇酯（PET），0.4μm孔，孔密度1.6×106cm 2），密度为2.5×104 cells cm2每口井。当它们在第5天达到汇合时，将不同的实验细胞组转移到含有减少量的FCS的分化培养基中，并如所示用TNFα或氢化可的松处理。
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数据来源文献
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[1]. F?rster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49.
[2]. Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9.
[3]. Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84.
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规格
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20mg 10mM*1mL (in DMSO) 100mg
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单位
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瓶
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