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| 产地 | 国产 |
| 品牌 | Solarbio |
| 货号 | IH0010 |
| 用途 | 抑制剂 |
| 包装规格 | 20mg |
| CAS编号 | 442-51-3 |
| 纯度 | 98% |
| 是否进口 | 否 |
| CAS | 442-51-3 |
| 中文名称 | 去氢骆驼蓬碱 |
| 英文名称 | Harmine |
| 别名 | Telepathine |
| 纯度 | HPLC≥98% |
| 分子式 | C13H12N2O |
| 分子量 | 212.25 |
| 外观（性状） | Off-white to brown Solid |
| 储存条件 | Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months |
| 溶解性 | Soluble in DMSO |
| EC | EINECS 207-131-4 |
| MDL | MFCD00004958 |
| InChIKey | BXNJHAXVSOCGBA-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 |
| PubChem CID | 5280953 |
| SMILES | CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3 |
| 描述 | (Harmine is a dual-specificity tyrosine phosphorylation-regulated kinase ((DYRK)) inhibitor with anticancer and anti-inflammatory activities.) |
| 靶点 | DYRK;PPARγ;5-HT Receptor;MAO-A |
| 通路 | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease;Neuronal Signaling;GPCR & G Protein;Protein Tyrosine Kinase/RTK |
| 生物活性 | Harmine是5-HT2A的抑制剂，Ki为397 nM [1]。 |
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| 动物实验 | 大鼠[4]共150只雄性Sprague-Dawley大鼠（年龄10-12周;体重280-320g;用于本研究。大鼠随机分为三组：假手术组（假手术组） ; n = 15）; TBI组（TBI; n = 35）和TBI + Harmine 组（Harmine; n = 35）。在TBI（ip，30 mg/kg/d）后立即给予Harmine用于向上假性和TBI组接受等体积的0.9％生理盐水（ip）。大鼠按如下分组进行行为恢复检查：Sham，n = 3; TBI，n = 7;和Harmine，n = 7.在TBI后，在 ,3和5天评估NSS。每只大鼠由对动物 不知情的观察者进行评估[4]。 |
| 数据来源文献 |
[1]. Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32. [2]. Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859. [3]. Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92. [4]. Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91. |
| 规格 | 20mg 10mM*1mL (in DMSO) 100mg |
| 单位 | 瓶 |
