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CAS
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231277-92-2
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中文名称
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拉帕替尼
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英文名称
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Lapatinib
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别名
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GW572016; GSK572016
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纯度
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HPLC≥98%
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分子式
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C29H26ClFN4O4S
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分子量
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581.06
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外观（性状）
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Light yellow to yellow Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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MDL
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MFCD09264194
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EC
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EINECS 1806241-263-5
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InChIKey
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BCFGMOOMADDAQU-UHFFFAOYSA-N
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InChI
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InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)
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PubChem CID
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208908
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SMILES
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O=S(CCNCC1=CC=C(C2=CC=C3C(C(NC4=CC(Cl)=C(C=C4)OCC5=CC(F)=CC=C5)=NC=N3)=C2)O1)(C)=O
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描述
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Lapatinib是有效的 EGFR 和 ErbB2 抑制剂。(Lapatinib is a potent EGFR and ErbB2 inhibitor.)
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靶点
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EGFR
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通路
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Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling
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