|
| 产地 | 国产 |
| 品牌 | Solarbio |
| 货号 | IL0250 |
| 用途 | |
| 包装规格 | 10mg 10mM*1mL (in DMSO) 50mg |
| CAS编号 | 491-70-3 |
| 纯度 | 98% |
| 是否进口 | 否 |
| CAS | 491-70-3 |
| 中文名称 | 木犀草素 |
| 英文名称 | Luteolin |
| 别名 | Digitoflavone;Luteoline;Luteolol;Flacitran |
| 纯度 | HPLC≥98% |
| 分子式 | C15H10O6 |
| 分子量 | 286.24 |
| 外观（性状） | Light yellow to yellow Solid |
| 储存条件 | Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months |
| 溶解性 | Soluble in DMSO ≥ 25mg/mL |
| EC | EINECS 207-741-0 |
| MDL | MFCD00017309 |
| InChIKey | IQPNAANSBPBGFQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H |
| PubChem CID | 5280445 |
| SMILES | O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13 |
| 描述 |
Luteolin是一种黄酮类化合物,是一种有效的 Nrf2 抑制剂和一种非选择性的PDE抑制 性。(Luteolin, a flavonoid, is a potent Nrf2 inhibitor and a non-selective PDE inhibitor with anti-inflammatory and anticancer activity.) |
| 靶点 | PDE;Nrf2 |
| 通路 | Metabolic Enzyme&Protease；NF-κB |
| 生物活性 | Luteolin is a potent PDE and Nrf2 inhibitor.Luteolin can protect against non-alcoholic steatohepatitis through targeting the pro-inflammatory IL-1 and Il-18 pathways in addition to an antioxidant effect.[1-3] |
