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CAS
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97682-44-5
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中文名称
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伊立替康
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英文名称
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Irinotecan
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别名
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(+)-Irinotecan;Topotecin;CPT-11
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纯度
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HPLC≥98%
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分子式
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C33H38N4O6
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分子量
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586.68
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外观（性状）
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Light yellow to yellow Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO ≥10mg/mL
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MDL
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MFCD01862255
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EC
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EINECS 691-567-9
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InChIKey
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UWKQSNNFCGGAFS-XIFFEERXSA-N
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InChI
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InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1
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PubChem CID
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60838
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SMILES
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O=C(N1CCC(N2CCCCC2)CC1)OC3=CC=C4N=C5C(CN6C(C(COC([C@@]7(CC)O)=O)=C7C=C65)=O)=C(CC)C4=C3
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描述
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Irinotecan是拓扑异构酶I抑制剂,通过与拓扑异构酶I-DNA复合物结合来防止DNA链的再连接。(Irinotecan is a topoisomerase I inhibitor that prevents religation of DNA strands by binding to the topoisomerase I-DNA complex.)
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靶点
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Topoisomerase
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通路
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DNA Damage/DNA Repair
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