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CAS
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2444-46-4
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中文名称
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合成辣椒碱
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英文名称
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Nonivamide
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别名
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洛里维德
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纯度
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HPLC≥98%
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分子式
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C17H27NO3
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分子量
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293.4
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO ≥10mg/mL
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MDL
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MFCD00017286
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EC
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EINECS 219-484-1
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InChIKey
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RGOVYLWUIBMPGK-UHFFFAOYSA-N
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InChI
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InChI=1S/C17H27NO3/c1-3-4-5-6-7-8-9-17(20)18-13-14-10-11-15(19)16(12-14)21-2/h10-12,19H,3-9,13H2,1-2H3,(H,18,20)
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PubChem CID
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2998
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SMILES
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CCCCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O
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描述
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Nonivamide是一种TRPV1激动剂。(Nonivamide is a TRPV1 agonist.)
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靶点
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TRPV1
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通路
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Membrane Transporter&Ion Channel;Neuronal Signaling
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生物活性
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TRPV1 agonist (nonivamide) treatment caused calcium release from the ER and altered the transcription of growth arrest- and DNA damage-inducible transcript 3 (GADD153)， GADD45alpha， GRP78/BiP， ATF3， CCND1， and CCNG2) in a manner comparable with prototypical ER stress-inducing agents.[1]
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数据来源文献
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[1]. Thomas KC， Sabnis AS， Johansen ME， Lanza DL， Moos PJ， Yost GS， Reilly CA. Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. J Pharmacol Exp Ther. 2007 Jun;321(3):830-8. doi: 10.1124/jpet.107.119412. Epub 2007 Mar 1. PMID: 17332266.
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规格
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10mg 10mM*1mL (in DMSO) 50mg 100mg
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单位
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瓶
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