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CAS
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137281-23-3
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中文名称
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培美曲塞酸
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英文名称
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Pemetrexed
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别名
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LY231514;Pemetrexed;LY-231514 Disodium Hydrate
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纯度
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HPLC≥98%
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分子式
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C20H21N5O6
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分子量
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427.41
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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MDL
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MFCD19105065
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EC
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EINECS 680-625-9
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InChIKey
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WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
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InChI
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InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1
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PubChem CID
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135410875
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SMILES
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O=C1NC(N)=NC2=C1C(CCC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)=CN2
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描述
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Pemetrexed是一种叶酸拮抗剂。抑制胸苷酸合成酶 (TS),二氢叶酸还原酶 (DHFR) 和甘氨酰胺核苷酸甲酰转移酶 (GARFT)。(Pemetrexed is a folic acid antagonist. Inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide nucleotide formyltransferase (GARFT).)
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靶点
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Antifolate
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通路
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Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease
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规格
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50mg 10mM*1mL (in DMSO) 100mg
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单位
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瓶
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