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CAS
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18642-23-4
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中文名称
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补骨脂定
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英文名称
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Psoralidin
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别名
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补骨酯定
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纯度
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HPLC≥98%
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分子式
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C20H16O5
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分子量
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336.34
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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MDL
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MFCD10566617
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InChIKey
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YABIJLLNNFURIJ-UHFFFAOYSA-N
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InChI
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InChI=1S/C20H16O5/c1-10(2)3-4-11-7-14-17(9-15(11)22)25-20(23)18-13-6-5-12(21)8-16(13)24-19(14)18/h3,5-9,21-22H,4H2,1-2H3
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PubChem CID
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5281806
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SMILES
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O=C1C2=C(OC3=CC(O)=CC=C32)C4=CC(C/C=C(C)\C)=C(O)C=C4O1
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描述
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Psoralidin 是雌激素受体 (ER)α 和 ERβ 的激动剂;也是 COX-2 和 5-LOX 的双重抑制剂。Psoralidin 显著下调 NOTCH1 信号传导。Psoralidin 还极大地诱导 ROS 产生。(Psoralidin is an agonist of estrogen receptor (ER)α and ERβ; It is also a dual inhibitor of COX-2 and 5-LOX. Psoralidin significantly down-regulates NOTCH1 signaling. Psoralidin also greatly induced ROS production.)
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靶点
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Estrogen Receptor;Notch;COX;ROS;5-LOX
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通路
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Stem Cells;Neuronal Signaling;Endocrinology & Hormones
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规格
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10mg 10mM*1mL (in DMSO) 50mg
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单位
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瓶
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