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CAS
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5578-73-4
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中文名称
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氯化血根碱
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英文名称
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Sanguinarine Chloride
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别名
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血根碱;Pseudochelerythrine chloride
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纯度
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HPLC≥98%
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分子式
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C20H14NO4Cl
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分子量
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367.78
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外观（性状）
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Orange to red Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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MDL
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MFCD00003004
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InChIKey
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GIZKAXHWLRYMLE-UHFFFAOYSA-M
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InChI
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InChI=1S/C20H14NO4.ClH/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21;/h2-8H,9-10H2,1H3;1H/q+1;/p-1
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PubChem CID
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68635
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SMILES
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C[N+]1=CC2=C3C(OCO3)=CC=C2C(C=CC4=C5)=C1C4=CC6=C5OCO6.[Cl-]
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描述
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Sanguinarine Chloride是一种生物碱,可通过激活活性氧 (ROS) 的产生来刺激细胞凋亡。诱导的细胞凋亡与 JNK 和 NF-κB 的活化有关。(Sanguinarine Chloride is an alkaloid that stimulates apoptosis by activating the production of reactive oxygen species (ROS). The induced apoptosis is associated with the activation of JNK and NF-κB.)
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靶点
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Apoptosis
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通路
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Apoptosis
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