|
CAS
|
95-25-0
|
|
中文名称
|
氯唑沙宗
|
|
英文名称
|
Chlorzoxazone
|
|
别名
|
Paraflex
|
|
纯度
|
HPLC≥98%
|
|
分子式
|
C7H4ClNO2
|
|
分子量
|
169.57
|
|
外观（性状）
|
White to off-white Solid
|
|
储存条件
|
Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
|
|
溶解性
|
Soluble in DMSO ≥ 25mg/mL
|
|
EC
|
EINECS 202-403-9
|
|
MDL
|
MFCD00005717
|
|
InChIKey
|
TZFWDZFKRBELIQ-UHFFFAOYSA-N
|
|
InChI
|
InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
|
|
PubChem CID
|
2733
|
|
SMILES
|
O=C1OC2=CC=C(Cl)C=C2N1
|
|
描述
|
Chlorzoxazone是一种作用于中枢的肌肉松弛剂。(Chlorzoxazone is a centrally acting muscle relaxant.)
|
|
靶点
|
Cytochrome P450
|
|
通路
|
Metabolic Enzyme&Protease
|
|
生物活性
|
Chlorzoxazone (CLZ) is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans. [1] Chlorzoxazone is a centrally acting muscle relaxant.[2]
|
|
数据来源文献
|
[1]. Yamamura Y， et al. Comprehensive kinetic analysis and influence of reaction components for chlorzoxazone 6-hydroxylation in human liver microsomes with CYP antibodies. Xenobiotica. 2015 Apr;45(4):353-360.
[2]. Cao Y， Dreixler JC， Roizen JD， Roberts MT， Houamed KM. Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds. J Pharmacol Exp Ther. 2001 Mar;296(3):683-9.
|
|
规格
|
25mg 50mg 100mg
|
