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| 产地 | 国产 |
| 品牌 | Solarbio |
| 货号 | IA0100 |
| 用途 | 科研 |
| 包装规格 | 50mg |
| CAS编号 | 58-61-7 |
| 纯度 | 98% |
| 是否进口 | 否 |
| CAS | 58-61-7 |
| 中文名称 | 腺苷 |
| 英文名称 | Adenosine |
| 别名 | D-Adenosine;Adenine riboside |
| 纯度 | HPLC≥98% |
| 分子式 | C10H13N5O4 |
| 分子量 | 267.24 |
| 外观（性状） | White to off-white Solid |
| 储存条件 | Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months |
| 溶解性 | Soluble in DMSO ≥10mg/mL |
| MDL | MFCD00005752 |
| EC | EINECS 200-389-9 |
| InChIKey | OIRDTQYFTABQOQ-KQYNXXCUSA-N |
| InChI | InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 |
| PubChem CID | 60961 |
| SMILES | NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2)=NC=N1 |
| 描述 | 腺苷是一种遍布人体细胞的内源性核苷,是用于合成三磷酸腺苷(ATP)、腺嘌呤、腺苷酸、阿糖腺苷的重要中间体。可直接进入心肌经磷酸化生成腺苷酸。(Adenosine is an endogenous nucleoside distributed throughout human cells and is an important intermediate for the synthesis of adenosine triphosphate (ATP), adenine, adenylate, and adenosine arabinoside. It can directly enter the myocardium to be phosphorylated to generate adenylate.) |
| 靶点 | DNA/RNA Synthesis |
| 通路 | Cell Cycle;DNA Damage/DNA Repair |
| 生物活性 | Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1-2]. |
| In Vitro | Adenosine (Adenine riboside) acts on four G-protein coupled receptors: two of them, A1 and A3, are primarily coupled to Gi family G proteins; and two of them, A2A and A2B, are mostly coupled to Gs like G proteins. These receptors are antagonized by xanthines including caffeine. Via these receptors it affects many cells and organs, usually having a cytoprotective function[2].Adenosine is an extracellular signaling molecule that is generated from its precursor molecules 5’-adenosine triphosphate (ATP) and 5’-adenosine monophosphate (AMP)[3].Adenosine is a common metabolite of ATP, which exhibits cytotoxic effects at high concentrations.Adenosine (1.0-4.0 mM; 12-24 hours) inhibits cell viability and triggers ER stress in HepG2 cells.Adenosine induces apoptosis in a variety of cancer cells. Adenosine (2.0 mM; 12-24 hours) induces autophagy in HepG2 cells. In HepG2 cell lines, Adenosine -induced AMPK/mTOR pathway activation partially blocked ER stress and decreased apoptotic cell death[4]. |
| 数据来源文献 |
[1]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14(7):1315-1323. [2]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625. [3]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009;111(4):904-915. [4]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2019;41(2):829-838. |
| 规格 | 50mg 10mM*1mL (in DMSO) 100mg |
| 单位 | 瓶 |
