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CAS
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71963-77-4
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中文名称
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蒿甲醚
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英文名称
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Artemether
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别名
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Dihydroartemisinin methyl ether;SM224;Dihydroqinghaosu methyl ether;CGP 56696
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纯度
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HPLC≥98%
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分子式
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C16H26O5
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分子量
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298.37
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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MDL
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MFCD00866205
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EC
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EINECS 663-549-0
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InChIKey
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SXYIRMFQILZOAM-HVNFFKDJSA-N
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InChI
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InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
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PubChem CID
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68911
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SMILES
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C[C@H]1[C@@H](OC)O[C@@]2([H])[C@]34[C@@]([C@H](C)CC[C@]41[H])([H])CC[C@@](O2)(C)OO3
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描述
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Artemether是一种具有抗疟疾活性的化合物(Artemether is a compound with antimalarial activity)
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靶点
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Parasite
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通路
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Anti-infection
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生物活性
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Artemether, a derivative of the antimalarial drug artemisinin. [1]
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In Vitro
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Artemether exhibits the highest activity against juvenile stages of the parasites, while adult worms are significantly less susceptible. There was no indication of neurotoxicity following repeated high doses of artemether given fortnightly for up to 5 months. [1]
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In Vivo
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There were remarkably inhibitory effects of artmeter on brain glioma growth and angiogenesis in SD rats and the mechanism that artemether inhibited brain glioma growth might be penetrating the blood-brain barrier and inhibiting angiogenesis.[2]
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动物实验
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Forty SD rats which were subcutaneous planted with SD rat C6 glioma cell to establish SD rat orthotopic glioma model were divided resourcefully into 5 groups. each group was 8 rats. Length-path (a mm) and short-path (b mm) of tumor each rat was measured. Tumor volume was calculated using the following formula: V (mm(3)) = a(2)bpi/6. Microvessel density (MVD) in different therapy groups was significantly lower than that in normal saline control group and brain glioma volume in different therapy groups was significantly smaller than that in normal saline control group.[2]
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数据来源文献
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[1]. Xiao, S., et al., Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia. Acta Trop, 2002. 82(2): p. 175-81.
[2]. Wu, Z.P., et al., Inhibitive effect of artemether on tumor growth and angiogenesis in the rat C6 orthotopic brain gliomas model. Integr Cancer Ther, 2009. 8(1): p. 88-92.
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规格
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10mg 10mM*1mL (in DMSO) 50mg 100mg
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单位
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瓶
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