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CAS
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339-72-0
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中文名称
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L-环丝氨酸
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英文名称
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L-Cycloserine
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别名
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Levcycloserine;Levcicloserina;Levcycloserinum;(-)-Cycloserine;(S)-Cycloserine;环丝氨酸;(S)-4-Amino-3-isoxazolidone
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纯度
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≥98%
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分子式
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C3H6N2O2
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分子量
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102.09
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in Water/DMSO ≥5mg/mL
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MDL
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MFCD00064324
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EC
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EINECS 206-427-0
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SMILES
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O=C1NOC[C@@H]1N
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描述
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L-cycloserine不可逆地抑制GABA 5'-磷酸吡哆醛氨基转移酶。还可以抑制3-酮二氢鞘氨醇合成酶。(L-cycloserine irreversibly inhibits GABA 5'-phosphate pyridoxal aminotransferase. Also inhibits 3-ketodihydrosphingosine synthase.)
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靶点
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3-ketodihydrosphingosine synthetase，GABA pyridoxal 5′-phosphate-dependent aminitransferase
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通路
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Others
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生物活性
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L-Cycloserine (Levcycloserine， Levcicloserina， Levcycloserinum， (-)-Cycloserine， (S)-Cycloserine) is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase.[1-3]
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In Vitro
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L-Cycloserine is a potent inhibitor of the first en zyme of the sphingolipid pathway， 3-ketodihydrosphin-gosine (3KDS) synthase (serine palmitoyltransferase) and causes an irreversible inhibition of 3KDS synthase derived from a bacterial source (Bacteroides levii) and from brain and heart microsomes in vitro[3].
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In Vivo
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Long-term administration of a low dosage of L-cycloserine subcutaneously to mice results in a significant reduction in the level of brain cerebrosides with little effect on other sphingolipids[3].
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数据来源文献
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[1] Williams RD， et al. J Lipid Res. 1987， 28(12):1478-81.
[2] Sundaram KS， et al. Antimicrob Agents Chemother. 1984， 26(2):211-3.
[3] Sundaram KS， et al. Neurochem Res. 1989， 14(3):245-8.
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规格
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5mg 10mg 20mg
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单位
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瓶
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