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CAS
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4350-09-8
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中文名称
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L-5-羟基色氨酸
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英文名称
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L-5-Hydroxytryptophan
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别名
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L-oxitriptan;5-羟基色氨酸;Oxitriptan;L-5-HTP
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纯度
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HPLC≥98%
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分子式
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C11H12N2O3
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分子量
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220.22
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : 2-8℃, 2 years; In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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EC
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EINECS 224-411-1
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MDL
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MFCD00064341
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SMILES
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N[C@@H](CC1=CNC2=CC=C(O)C=C12)C(O)=O
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描述
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L-5-Hydroxytryptophan (L-5-HTP) 是一种天然氨基酸和膳食补充剂,神经递质血清素的前体,以及reserpine 的拮抗剂。(L-5-Hydroxytryptophan (L-5-HTP) is a natural amino acid and dietary supplement, precursor of the neurotransmitter serotonin, and antagonist of reserpine.)
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靶点
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Others
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通路
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Others
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生物活性
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5-Hydroxytryptophan (5-HTP, L-oxitriptan), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin.[1-2]
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In Vitro
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5-Hydroxytryptophan (5-HTP) is a 5-HT precursor. In Caco-2 cells, exogenous 5-HTP, which can enter the cells, increases the density of microvilli[1].
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In Vivo
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Systemic application of 5-HTP increases the density of microvilli in the mouse intestine in vivo[1] and allows frontal cortical serotonin response to stress in hyperphenylalaninaemic mice[2].
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细胞实验
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Animal Models: The homozygote (–/–) PahEnu2 (ENU2) and homozygote (+/+) PahEnu2 [wild type (WT)] mice; Dosages: 2.5, 5, 10, 20 mg/kg;i.p.[2]
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数据来源文献
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[1] Nakamura K, et al. Int J Tryptophan Res. 2009, 2:37-43.
[2] Pascucci T, et al. Int J Neuropsychopharmacol. 2009, 12(8):1
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规格
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100mg 10mM*1mL in DMSO 200mg
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单位
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瓶
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